Mioste
Medical Innovation and Smart Technologies
The group “Medical Innovation and Smart Technologies (MIOSTE)” was founded by Stefan Stübinger and Miodrag Savic. The primary aim is to foster advances in clinically oriented research, emerging technologies and innovative product development. Principal fields of interest are translational medicine including prototyping, experimental surgical techniques, regenerative medicine, applied biotechnology and molecular medicine with a focus on body fluids. Embedded within the University Hospital Basel, MIOSTE offers an open and interdisciplinary research unit for various disciplines and creates strategical collaborations developing novel and pragmatic approaches for solving complex health problems.
People

Miodrag Savic

Stefan Stübinger

Tobias Schindler

Martin Sailer

Matthias Buhmann
Mission and Vision
Our vision is to push forward and implement the development and application of innovation in medicine and surgery by conducting research and development focusing on improving state-of-the-art technologies as well as cutting-edge technologies. We provide scientific collaboration opportunities based on an international network with interdisciplinary research groups. The mindset of MIOSTE is to establish creative solutions with a high level of reliability, efficiency and usability.
Uniting and incorporating clinically oriented and basic research activities within an entrepreneurial environment creates a sound hotbed for forward-looking medical innovations and smart technologies from bed to bench and bench to bed.
Selected Publications
- Marginal bone loss one year after implantation: a systematic review of different loading protocols. Int J Oral Maxillofac Surg. 2020 ;49(1):121–134
Sommer M, Zimmermann J, Grize L, Stübinger S.
- Diagnosing peri-implant disease using the tongue as a 24/7 detector. Nat Commun. 2017 15;8:264.
Ritzer J, Lühmann T, Rode C, Pein-Hackelbusch M, Immohr I, Schedler U, Thiele T, Stübinger S, Rechenberg BV, Waser-Althaus J, Schlottig F, Merli M, Dawe H, Karpíšek M, Wyrwa R, Schnabelrauch M, Meinel L
- Titanium and hydroxyapatite coating of polyetheretherketone and carbon fiber-reinforced polyetheretherketone: A pilot study in sheep. J Biomed Mater Res B Appl Biomater. 2016;104:1182–91
Stübinger S, Drechsler A, Bürki A, Klein K, Kronen P, von Rechenberg B
- Osseointegration of titanium implants functionalised with phosphoserine-tethered poly(epsilon-lysine) dendrons: a comparative study with traditional surface treatments in sheep. J Mater Sci Mater Med. 2015;26:87.
Stübinger S, Nuss K, Bürki A, Mosch I, le Sidler M, Meikle ST, von Rechenberg B, Santin M
- Wastewater monitoring of SARS-CoV‑2 shows high correlation with COVID-19 case numbers and allowed early detection of the first confirmed B.1.1.529 infection in Switzerland: results of an observational surveillance study.
Med Wkly. 2022 Jun 27;152:w30202. doi: 10.4414/smw.2022.w30202. eCollection 2022 Jun 20.PMID: 35822578
Bagutti C, Alt Hug M, Heim P, Maurer Pekerman L, Ilg Hampe E, Hübner P, Fuchs S, Savic M, Stadler T, Topolsky I, Icer Baykal P, Dreifuss D, Beerenwinkel N, Tschudin Sutter S.Swiss
- Congenital orbital teratoma: A clinicopathologic case report.
Am J Ophthalmol Case Rep. 2022 Feb 11;26:101420. doi: 10.1016/j.ajoc.2022.101420. eCollection 2022 Jun.PMID: 35243160
Reinhold A, Meyer P, Bruder E, Soleman J, von der Weid N, Mueller AA, Savic M.
- DeepSARS: simultaneous diagnostic detection and genomic surveillance of SARS-CoV‑2. BMC Genomics. 2022 Apr 11;23(1):289. doi: 10.1186/s12864-022–08403‑0.PMID: 35410128
Yermanos A, Hong KL, Agrafiotis A, Han J, Nadeau S, Valenzuela C, Azizoglu A, Ehling R, Gao B, Spahr M, Neumeier D, Chang CH, Dounas A, Petrillo E, Nissen I, Burcklen E, Feldkamp M, Beisel C, Oxenius A, Savic M, Stadler T, Rudolf F, Reddy ST
- SARS-CoV‑2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display. Cell Rep. 2022 Jan 18;38(3):110242. doi: 10.1016/j.celrep.2021.110242. Epub 2021 Dec 22.PMID: 34998467
Ehling RA, Weber CR, Mason DM, Friedensohn S, Wagner B, Bieberich F, Kapetanovic E, Vazquez-Lombardi R, Di Roberto RB, Hong KL, Wagner C, Pataia M, Overath MD, Sheward DJ, Murrell B, Yermanos A, Cuny AP, Savic M, Rudolf F, Reddy ST
- A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients.
ST.Front Immunol. 2021 Jul 12;12:701085. doi: 10.3389/fimmu.2021.701085. eCollection 2021.PMID: 34322127
Bieberich F, Vazquez-Lombardi R, Yermanos A, Ehling RA, Mason DM, Wagner B, Kapetanovic E, Di Roberto RB, Weber CR, Savic M, Rudolf F, Reddy
- Retrobulbar haematoma in the era of anticoagulants.
Injury. 2019 Oct;50(10):1641–1648. doi: 10.1016/j.injury.2019.08.035. Epub 2019 Aug 20.PMID: 31519435
Berg BI, Flury E, Thieringer FM, Augello M, Savic M, Schötzau A, Kunz C, Goldblum D
- Evaluation of Two 3D Printers for Guided Implant Surgery.
Int J Oral Maxillofac Implants. 2018 July/August;33(4):743–746. doi: 10.11607/jomi.6074. Epub 2018 Mar 15.PMID: 29543930
Sommacal B, Savic M*, Filippi A, Kühl S, Thieringer FM
- Progenitor cell therapy for sacral pressure sore: a pilot study with a novel human chronic wound model.
Stem Cell Res Ther. 2014 Jan 29;5(1):18. doi: 10.1186/scrt407.PMID: 24476740*Co-first author
Wettstein R, Savic M*, Pierer G, Scheufler O, Haug M, Halter J, Gratwohl A, Baumberger M, Schaefer DJ, Kalbermatten DF